{"id":1428,"date":"2026-08-11T06:56:51","date_gmt":"2026-08-11T06:56:51","guid":{"rendered":"https:\/\/sites.abo.fi\/madness\/?post_type=events&#038;p=1428"},"modified":"2026-08-11T06:56:52","modified_gmt":"2026-08-11T06:56:52","slug":"guest-seminar-resolving-organelle-destruction-in-physiological-space-and-time","status":"publish","type":"events","link":"https:\/\/sites.abo.fi\/madness\/events\/guest-seminar-resolving-organelle-destruction-in-physiological-space-and-time\/","title":{"rendered":"Guest Seminar: Resolving organelle destruction in physiological space and time"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Guest Seminar<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">20<sup>th<\/sup> August at 15:15<br>Onsite event<br>in Lauren 2, Medisiina D<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Tom McWilliams<\/strong>, University of Helsinki<br><em>Resolving organelle destruction in physiological space and time<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Host: Eeva-Liisa Eskelinen (<a href=\"mailto:eeva-liisa.eskelinen@utu.fi\">eeva-liisa.eskelinen@utu.fi<\/a>)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Coffee will be served at 14:45<br>Tom will be the opponent of Mauricio Ramm\u2019s PhD thesis on Friday August 21.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tom McWilliams is Associate Professor of Mitochondrial Medicine at the University of Helsinki. Originally from Ireland, Tom studied Biochemistry in Galway before completing his PhD in Integrative Neuroscience with Alun Davies and Steve Dunnett. As a postdoctoral fellow at the MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, Scotland, Tom co-developed the <em>mito<\/em>-QC mitophagy-reporter mouse with Ian Ganley, and studied degeneration signalling in the context of Parkinson&#8217;s disease with Miratul Muqit. His group in Helsinki combines <em>in vivo <\/em>cell biology approaches with biochemistry, genetics and imaging to understand the metabolic regulation of physiological autophagy in health and disease. <a href=\"http:\/\/www.mcwilliamslab.eu\">www.mcwilliamslab.eu<\/a>&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Selected Publications<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Rappe et al., (2024) Longitudinal autophagy profiling of the mammalian brain reveals sustained mitophagy throughout healthy aging. The EMBO Journal.&nbsp;Dec;43(23):6199-6231. doi: 10.1038\/s44318-024-00241-y. Epub 2024 Oct 4. PMID: 39367235; PMCID: PMC11612485.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Long M et al.,&nbsp;(2022) DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron\u2009depletion. The EMBO Journal.&nbsp;May 16;41(10):e109390. doi: 10.15252\/embj.2021109390. Epub 2022 Apr 12. PMID: 35411952; PMCID: PMC9108618.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Collier JJ et al.,&nbsp;(2021) Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans. New England Journal of Medicine. Jun 24;384(25):2406-2417. doi: 10.1056\/NEJMoa1915722. PMID: 34161705; PMCID: PMC7611730.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Guest Seminar 20th August at 15:15Onsite eventin Lauren 2, Medisiina D Tom McWilliams, University of HelsinkiResolving organelle destruction in physiological space and time Host: Eeva-Liisa Eskelinen (eeva-liisa.eskelinen@utu.fi) Coffee will be served at 14:45Tom will be the opponent of Mauricio Ramm\u2019s PhD thesis on Friday August 21. Tom McWilliams is Associate Professor of Mitochondrial Medicine at&#8230;<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":true,"inline_featured_image":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"categories":[],"tags":[],"class_list":["post-1428","events","type-events","status-publish","hentry"],"acf":[],"lang":"en","translations":{"en":1428},"taxonomy_info":[],"featured_image_src_large":false,"author_info":[],"comment_info":"","pll_sync_post":[],"_links":{"self":[{"href":"https:\/\/sites.abo.fi\/madness\/wp-json\/wp\/v2\/events\/1428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.abo.fi\/madness\/wp-json\/wp\/v2\/events"}],"about":[{"href":"https:\/\/sites.abo.fi\/madness\/wp-json\/wp\/v2\/types\/events"}],"wp:attachment":[{"href":"https:\/\/sites.abo.fi\/madness\/wp-json\/wp\/v2\/media?parent=1428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.abo.fi\/madness\/wp-json\/wp\/v2\/categories?post=1428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.abo.fi\/madness\/wp-json\/wp\/v2\/tags?post=1428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}