{"id":1427,"date":"2026-08-11T06:56:09","date_gmt":"2026-08-11T06:56:09","guid":{"rendered":"https:\/\/sites.abo.fi\/madness\/?post_type=events&p=1427"},"modified":"2026-08-11T06:56:10","modified_gmt":"2026-08-11T06:56:10","slug":"biocity-turku-guest-seminar-decoding-gtp-energy-metabolism-insights-into-molecular-oncogenesis-and-immunotherapy","status":"publish","type":"events","link":"https:\/\/sites.abo.fi\/madness\/events\/biocity-turku-guest-seminar-decoding-gtp-energy-metabolism-insights-into-molecular-oncogenesis-and-immunotherapy\/","title":{"rendered":"BioCity Turku Guest Seminar: Decoding GTP energy metabolism: insights into molecular oncogenesis and immunotherapy"},"content":{"rendered":"\n

BioCity Turku Guest Seminar<\/strong><\/p>\n\n\n\n

20th<\/sup> August at 12:00-13:30
Onsite event
in Presidentti auditorium, BioCity<\/p>\n\n\n\n

Coffee and sandwich at 11:45<\/p>\n\n\n\n

Prof. Atsuo T. Sasaki<\/strong>, University of Cincinnati College of Medicine, USA
Decoding GTP energy metabolism: insights into molecular oncogenesis and immunotherapy<\/p>\n\n\n\n

and<\/p>\n\n\n\n

Prof. Toshiya Senda<\/strong>, High Energy Accelerator Research Organization (KEK), Structural Biology Research Center, Japan
Crossroads of Cell Biology and Structural Biology: How Structural Biology Contributes to GTP Metabolism Studies<\/p>\n\n\n\n

Host: Kari Kopra (kari.kopra@utu.fi<\/a>)<\/p>\n\n\n\n

Atsuo T. Sasaki is Professor of Medicine at the University of Cincinnati College of Medicine and Project Professor at Keio University\u2019s Institute for Advanced Biosciences. His research focuses on GTP energy metabolism at the interface of signaling, growth control, cancer biology, and therapeutic development. His laboratory discovered the mammalian GTP sensor PI5P4K\u03b2 and glioma GTP metabolic rewiring that supports ribosome biogenesis and proliferation. His group now develops GTP-GEEKS approaches to understand and target GTP-dependent biological programs. He is a 2022 Human Frontier Science Program Program Grant awardee.<\/p>\n\n\n\n

Toshiya Senda is a Professor, Head of Synchrotron Radiation Science Division II, and Director of the Structural Biology Research Center at the Institute of Materials Structure Science, KEK. He employs multidisciplinary approaches to study histone chaperones, pathogenic signaling by Helicobacter pylori, and the catalytic mechanisms of redox enzymes. Over the past decade, as a member of the “GTP Geeks,” he has focused on the structural biology aspects of GTP metabolism.<\/p>\n\n\n\n

Selected publications<\/strong><\/p>\n\n\n\n

Matsugaki N, Senda T. Advances in macromolecular crystallography at the Photon Factory: automation from crystallization to structural determination. J Synchrotron Radiat. 2025, 32, 567-576. doi:10.1107\/S1600577525001407<\/p>\n\n\n\n

Ogawa-Iio, Takeuchi K, Shigemi K, \u2026, Hashizume R, Osuka S, Goyama S, Yasuda T, Senda T, Sasaki AT IMPDH and GTP metabolism in cancer: Mechanisms, regulation, and translational scope. Cancer Sci. 2025, 116, 3250-3265. doi:10.1111\/cas.70200<\/p>\n\n\n\n

Takeuchi K, Senda M, Ikeda Y, Okuwaki K, Fukuzawa K, Nakagawa S, Sasaki M, Sasaki AT, Senda T. Functional molecular evolution of a GTP sensing kinase: PI5P4K\u03b2. FEBS J. 2023, 290, 4419-4428. doi:10.1111\/febs.16763<\/p>\n\n\n\n

Takeuchi K, Ikeda Y, Senda M, \u2026, Fujii Y, Sasaki AT, Senda T. The GTP responsiveness of PI5P4K\u03b2 evolved from a compromised trade-off between activity and specificity. Structure. 2022, 30, 886-899. doi:10.1016\/j.str.2022.04.004<\/p>\n\n\n\n

Kofuji S, Hirayama A, \u2026, Wakimoto H, Holland EC, Yong WH, Horbinski C, Nakano I, DeBerardinis RJ, Bachoo RM, Mischel PS, Yasui W, Suematsu M, Saya H, Soga T, Grummt I, Bierhoff H, Sasaki AT. IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma. Nat Cell Biol. 2019 Aug;21(8):1003-1014. doi: 10.1038\/s41556-019-0363-9.<\/p>\n","protected":false},"excerpt":{"rendered":"

BioCity Turku Guest Seminar 20th August at 12:00-13:30Onsite eventin Presidentti auditorium, BioCity Coffee and sandwich at 11:45 Prof. Atsuo T. Sasaki, University of Cincinnati College of Medicine, USADecoding GTP energy metabolism: insights into molecular oncogenesis and immunotherapy and Prof. Toshiya Senda, High Energy Accelerator Research Organization (KEK), Structural Biology Research Center, JapanCrossroads of Cell Biology…<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":true,"inline_featured_image":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"categories":[],"tags":[],"class_list":["post-1427","events","type-events","status-publish","hentry"],"acf":[],"lang":"en","translations":{"en":1427},"taxonomy_info":[],"featured_image_src_large":false,"author_info":[],"comment_info":"","pll_sync_post":[],"_links":{"self":[{"href":"https:\/\/sites.abo.fi\/madness\/wp-json\/wp\/v2\/events\/1427","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.abo.fi\/madness\/wp-json\/wp\/v2\/events"}],"about":[{"href":"https:\/\/sites.abo.fi\/madness\/wp-json\/wp\/v2\/types\/events"}],"wp:attachment":[{"href":"https:\/\/sites.abo.fi\/madness\/wp-json\/wp\/v2\/media?parent=1427"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.abo.fi\/madness\/wp-json\/wp\/v2\/categories?post=1427"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.abo.fi\/madness\/wp-json\/wp\/v2\/tags?post=1427"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}