Guest Seminar
20th August at 15:15
Onsite event
in Lauren 2, Medisiina D
Tom McWilliams, University of Helsinki
Resolving organelle destruction in physiological space and time
Host: Eeva-Liisa Eskelinen (eeva-liisa.eskelinen@utu.fi)
Coffee will be served at 14:45
Tom will be the opponent of Mauricio Ramm’s PhD thesis on Friday August 21.
Tom McWilliams is Associate Professor of Mitochondrial Medicine at the University of Helsinki. Originally from Ireland, Tom studied Biochemistry in Galway before completing his PhD in Integrative Neuroscience with Alun Davies and Steve Dunnett. As a postdoctoral fellow at the MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, Scotland, Tom co-developed the mito-QC mitophagy-reporter mouse with Ian Ganley, and studied degeneration signalling in the context of Parkinson’s disease with Miratul Muqit. His group in Helsinki combines in vivo cell biology approaches with biochemistry, genetics and imaging to understand the metabolic regulation of physiological autophagy in health and disease. www.mcwilliamslab.eu
Selected Publications
Rappe et al., (2024) Longitudinal autophagy profiling of the mammalian brain reveals sustained mitophagy throughout healthy aging. The EMBO Journal. Dec;43(23):6199-6231. doi: 10.1038/s44318-024-00241-y. Epub 2024 Oct 4. PMID: 39367235; PMCID: PMC11612485.
Long M et al., (2022) DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion. The EMBO Journal. May 16;41(10):e109390. doi: 10.15252/embj.2021109390. Epub 2022 Apr 12. PMID: 35411952; PMCID: PMC9108618.
Collier JJ et al., (2021) Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans. New England Journal of Medicine. Jun 24;384(25):2406-2417. doi: 10.1056/NEJMoa1915722. PMID: 34161705; PMCID: PMC7611730.
